Megf8 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including axon development; embryonic morphogenesis; and left/right pattern formation. Predicted to act upstream of or within several processes, including blood vessel development; embryonic brain development; and embryonic digit morphogenesis. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Predicted to be active in basement membrane. Human ortholog(s) of this gene implicated in Carpenter syndrome 2. Orthologous to human MEGF8 (multiple EGF like domains 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Megf8 |
| Official Name | multiple EGF-like-domains 8 [Source:RGD Symbol;Acc:621190] |
| Ensembl ID | ENSRNOG00000052687 |
| Bio databases IDs | |
| Aliases | multiple EGF-like-domains 8 |
| Synonyms | AW049492, b2b1702.2Clo, b2b1702Clo, b2b288Clo, C19orf49, CRPT2, EG628781, EGFL4, LOC269878, m687Ddg, mKIAA0817, multiple EGF-like-domains 8, SBP1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Megf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Laminin-type epidermal growth factor-like domai
- Galactose oxidase, central domain
- Kelch motif
- Plexin repeat
- CUB
- EGF domain
- protein binding
- Laminin EGF domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Carpenter syndrome type 2
- acrocephalopolysyndactyly type II
- stenosis
- atrial septal defect
- congenital heart disease
- exencephaly
- edema
- ventricular septal defect
- preaxial polydactyly
regulated by
- MIR17HG
- AR
regulates
- protein-protein complex
role in cell
- outgrowth
- fasciculation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Megf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic heart tube left/right pattern formation
- determination of heart left/right asymmetry
- determination of digestive tract left/right asymmetry
- coronary vasculature development
- craniofacial suture morphogenesis
- positive regulation of axon extension involved in axon guidance
- embryonic heart tube morphogenesis
- left/right pattern formation
- negative regulation of smoothened signaling pathway
- embryonic skeletal system morphogenesis
- fasciculation of sensory neuron axon
- embryonic limb morphogenesis
- cell migration involved in gastrulation
- BMP signaling pathway
- regulation of gene expression
- epiboly involved in gastrulation with mouth forming second
- limb morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding