Atxn7 Gene Summary [Rat]
Predicted to enable chromatin binding activity. Predicted to be involved in microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 7. Orthologous to human ATXN7 (ataxin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atxn7 |
| Official Name | ataxin 7 [Source:RGD Symbol;Acc:1562692] |
| Ensembl ID | ENSRNOG00000007246 |
| Bio databases IDs | |
| Aliases | ataxin 7 |
| Synonyms | A430107N12RIK, ADCAII, ATAXIN-7, OPCA3, RGD1562692, SCA7, SGF73 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atxn7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SCA7, zinc-binding domain
- nuclear export signal
- polyglutamine repeat
- glutamine repeat domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- non-insulin-dependent diabetes mellitus
- schizophrenia
- ataxia
- spinocerebellar ataxia type 7
- diabetes mellitus
- diabetic nephropathy
- breast carcinoma
- early missed abortion
- motor dysfunction
role in cell
- expression in
- quantity
- cell death
- binding in
- organization
- formation
- inhibition in
- degeneration
- aggregation in
- dysfunction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atxn7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- regulation of DNA repair
- negative regulation of microtubule depolymerization
- microtubule cytoskeleton organization
- visual perception
- nucleus organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- transcription factor TFTC complex
- cytosol
- nuclear matrix
- nucleolus
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding