Atp6ap1 Gene Summary [Rat]
Predicted to enable ATPase activator activity; small GTPase binding activity; and transporter activator activity. Predicted to be involved in several processes, including endosome to plasma membrane protein transport; intracellular monoatomic cation homeostasis; and synaptic vesicle lumen acidification. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6ap1 |
| Official Name | ATPase H+ transporting accessory protein 1 [Source:RGD Symbol;Acc:620423] |
| Ensembl ID | ENSRNOG00000054352 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting accessory protein 1 |
| Synonyms | 16A, AC45, AI316502, ATP6IP1, ATP6S1, ATPase H+ transporting accessory protein 1, ATPase, H+ transporting, lysosomal accessory protein 1, AW108110, C7-1, CF2, mFLJ00383, Vacuolar ATP synthase subunit s1, V-ATPase S1 subunit, VATPS1, XAP-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6ap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase stimulator
- Lysosome-associated membrane glycoprotein (Lamp)
- H+-transporting two-sector ATPase
- enzyme binding
- V-type proton ATPase subunit S1, luminal domain
- protein binding
- transporter
- V0 complex accessory subunit Ac45/VOA1 transmembrane domain
Pathways
Biological processes and signaling networks where the Atp6ap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 2
- immunodeficiency 47
- placental cancer
role in cell
- activity
- replication in
- growth
- morphology
- invasiveness
- osteoclastogenesis
- endocytosis by
- Clathrin mediated endocytosis by
- homeostasis in
- transit in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- cellular membrane
- endosomal membrane
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6ap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- osteoclast development
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- vacuolar acidification
- regulation of cellular pH
Cellular Component
Where in the cell the gene product is active
- proton-transporting two-sector ATPase complex
- proton-transporting V-type ATPase complex
- Golgi membrane
- plasma membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- endosome membrane
- synaptic vesicle membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- ATPase activator activity