Atp6v0a2 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement and proton transmembrane transport. Predicted to be located in cytoplasm; microtubule; and motile cilium. Predicted to be part of dynein complex. Human ortholog(s) of this gene implicated in spermatogenic failure 56. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v0a2 |
| Official Name | ATPase H+ transporting V0 subunit a2 [Source:RGD Symbol;Acc:621006] |
| Ensembl ID | ENSRNOG00000052704 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V0 subunit a2 |
| Synonyms | 8430408C20Rik, A2, a2V, ARCL, ARCL2A, ATP6A2, ATP6N1D, Atp6n2, Atp6v0a2 predicted, ATPase, H+ transporting, lysosomal V0 subunit A2, ATPase H+ transporting V0 subunit a2, Cc1-3, ISF, J6B7, RTF, SHIF, STV1, TJ6, TJ6M, TJ6S, V-ATPase 116 kDa, V-ATPase a2, V-ATPase V0-a2, VPH1, WSS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v0a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ETGE motif
- protein binding
- cytosolic tail domain
- V-type ATPase 116kDa subunit family
- transporter
Pathways
Biological processes and signaling networks where the Atp6v0a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- congenital disorder of glycosylation type 1l
- autosomal recessive cutis laxa type 2A
- cutis laxa
- hereditary disorder
- wrinkly skin syndrome
role in cell
- expression in
- quantity
- proliferation
- activation
- production in
- pH
- homeostasis in
- endocytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- organelle
- apical compartment
- perinuclear region
- cellular membrane
- focal adhesions
- Plasma Membrane
- endosomes
- endosomal membrane
- acrosome
- early endosomes
- apical vesicles
- phagosomes
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v0a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- immune response
- regulation of macroautophagy
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- proton-transporting V-type ATPase complex
- Golgi membrane
- plasma membrane
- lysosomal membrane
- vacuolar proton-transporting V-type ATPase, V0 domain
- perinuclear region of cytoplasm
- focal adhesion
- intracellular membrane-bounded organelle
- acrosomal vesicle
- vacuolar proton-transporting V-type ATPase complex
- phagocytic vesicle membrane
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism
- ATPase binding