Gsdmc Gene Summary [Rat]
Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptotic inflammatory response. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsdmc |
| Official Name | gasdermin C [Source:RGD Symbol;Acc:1308989] |
| Ensembl ID | ENSRNOG00000054576 |
| Bio databases IDs | |
| Aliases | gasdermin C |
| Synonyms | gasdermin C, Gsdmc1, MLZE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gsdmc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- channel/pore class transporter
- Gasdermin PUB domain
- Gasdermin pore forming domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- osteoarthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- atopic dermatitis
- ulcerative colitis
- Crohn disease
- systemic juvenile idiopathic arthritis
regulates
- IL33
- olaparib
role in cell
- apoptosis
- pyroptosis
- olaparib sensitivity
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gsdmc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyroptosis
- defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylinositol-4-phosphate binding
- phosphatidylserine binding