Casp8 Gene Summary [Rat]
Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to anesthetic; response to estradiol; and response to lipopolysaccharide. Located in cell body and cytosol. Part of CD95 death-inducing signaling complex. Used to study epilepsy and pre-malignant neoplasm. Biomarker of several diseases, including brain disease (multiple); heart disease (multiple); kidney disease (multiple); lung disease (multiple); and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp8 |
| Official Name | caspase 8 [Source:RGD Symbol;Acc:620945] |
| Ensembl ID | ENSRNOG00000012331 |
| Bio databases IDs | |
| Aliases | caspase 8 |
| Synonyms | ALPS2B, CAP4, Cas 8, Caspase-8, FLICE, MACH, MCH5, PROCASP8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- death receptor binding
- death effector domain-interacting domain
- peptidase
- caspase activator
- cleavage site
- identical protein binding
- CASc
- cysteine-type peptidase
- cysteine endopeptidase
- ubiquitin protein ligase binding
- tumor necrosis factor receptor binding
- catalytic domain
- caspase homology domain
- protein domain specific binding
- protein binding
- phosphorylation site
- protease domain
- Ced3-homology domain
- apoptosis activation domain
- endopeptidase
- binding protein
- active site
- FADD-like prodomain
- pro domain
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Casp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apoptosis Signaling
- CD27 Signaling in Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Death Receptor Signaling
- DNA damage-induced 14-3-3σ Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Granzyme B Signaling
- Induction of Apoptosis by HIV1
- Inflammasome pathway
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- PEDF Signaling
- Retinoic acid Mediated Apoptosis Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Sphingosine-1-phosphate Signaling
- TNFR1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gout
- colorectal cancer
- acute myeloid leukemia
- cancer
- septic shock
- heart failure
- amyotrophic lateral sclerosis
- hepatocellular carcinoma
- non-small cell lung cancer
regulated by
- P glycoprotein
- lipopolysaccharide
- palmitic acid
- thapsigargin
- PKC
- NMDA receptor
- ethanol
- CCK
- nitric oxide
- ionomycin
role in cell
- activation in
- expression in
- phosphorylation in
- apoptosis
- synthesis in
- migration
- activation
- binding in
- production in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Plasma Membrane
- Mitochondria
- cytosol
- membrane ruffles
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial outer membrane
- mitochondrial inner membrane
- nuclear foci
- nucleoplasm
- membrane rafts
- perikaryon
- lamellipodia
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Casp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extrinsic apoptotic signaling pathway
- T cell activation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- apoptotic signaling pathway
- positive regulation of proteolysis
- B cell activation
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- induction of apoptosis via death domain receptors
- execution phase of apoptosis
- positive regulation of neuron apoptotic process
- negative regulation of necroptosis
- self proteolysis
- heart development
- response to ethanol
- activation of cysteine-type endopeptidase activity
- angiogenesis
- positive regulation of macrophage differentiation
- apoptotic process
- pyroptosis
- response to cobalt ion
- protein maturation
- natural killer cell activation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- proteolysis involved in cellular protein catabolic process
- macrophage differentiation
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development
- cellular response to mechanical stimulus
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of innate immune response
- positive regulation of apoptotic process
- proteolysis
- response to estradiol stimulus
- response to lipopolysaccharide
- regulation of cytokine production
- cellular response to organic cyclic compound
- positive regulation of interleukin-1 beta production
- response to tumor necrosis factor
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- cell body
- mitochondrion
- cytosol
- death-inducing signaling complex
- macromolecular complex
- CD95 death-inducing signaling complex
- mitochondrial outer membrane
- lamellipodium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- cysteine-type endopeptidase activity
- tumor necrosis factor receptor binding
- death receptor binding
- cysteine-type peptidase activity
- peptidase activity
- cysteine-type endopeptidase activity involved in apoptotic process
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- scaffold protein binding
- protein binding
- ubiquitin protein ligase binding
- death effector domain binding