Acot1 Gene Summary [Rat]
Enables fatty acyl-CoA hydrolase activity. Involved in long-chain fatty acid metabolic process and negative regulation of cardiac muscle cell apoptotic process. Predicted to be located in cytosol and mitochondrion. Orthologous to human ACOT1 (acyl-CoA thioesterase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot1 |
| Official Name | acyl-CoA thioesterase 1 [Source:RGD Symbol;Acc:70894] |
| Ensembl ID | ENSRNOG00000055221 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 1 |
| Synonyms | ACH2, Acyl-CoA Thioesterase, acyl-CoA thioesterase 1, CTE-1, CTE-I, Cytosolic long chain acyl-CoA hydrolase, D12Ucla1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acot1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dienelactone hydrolase family
- alpha/beta hydrolases
- Acyl-CoA thioester hydrolase/BAAT N-terminal region
- enzyme
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol