Ascc1 Gene Summary [Rat]
Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be part of DNA repair complex and transcription regulator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus. Orthologous to human ASCC1 (activating signal cointegrator 1 complex subunit 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ascc1 |
| Official Name | activating signal cointegrator 1 complex subunit 1 [Source:RGD Symbol;Acc:1359255] |
| Ensembl ID | ENSRNOG00000056647 |
| Bio databases IDs | |
| Aliases | activating signal cointegrator 1 complex subunit 1 |
| Synonyms | 1810015P09RIK, activating signal cointegrator 1 complex subunit 1, AI550520, Asc-1, ASC1p50, CGI-18, p50, SMABF2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ascc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- K homology (KH) RNA-binding domain, type I
- KH domain
- AKAP7 2'5' RNA ligase-like domain
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- major depression
- esophageal cancer
- epithelial cancer
- hereditary disorder
- dementia
- endometriosis
- sarcoidosis
- spinal muscular atrophy with congenital bone fractures 2
- epithelial neoplasia
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ascc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA dealkylation involved in DNA repair
- DNA duplex unwinding
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear speck
- neuromuscular junction
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding