Slc5a6 Gene Summary [Rat]
Enables sodium-dependent multivitamin transmembrane transporter activity. Involved in biotin transport and pantothenate transmembrane transport. Located in brush border membrane. Orthologous to human SLC5A6 (solute carrier family 5 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc5a6 |
| Official Name | solute carrier family 5 member 6 [Source:RGD Symbol;Acc:69648] |
| Ensembl ID | ENSRNOG00000057628 |
| Bio databases IDs | |
| Aliases | solute carrier family 5 member 6 |
| Synonyms | COMNB, DKFZp434F152, E430023I20, hSMVT, NERIB, SMVT, SMVTD, solute carrier family 5 member 6, solute carrier family 5 (sodium-dependent vitamin transporter), member 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc5a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- amide transporter
- monocarboxylate porter
- pantothenate transporter
- Solute carrier families 5 and 6-like; solute binding domain
- sodium dependent multivitamin transporter
- protein binding
- biotin transporter
- iodide transporter
- transporter
- pantothenate:sodium symporter
- organic acid:sodium symporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal cell carcinoma
- biotin-responsive childhood-onset peripheral motor neuropathy
- biotin-responsive infantile-onset neurodegeneration
- renal cell cancer
regulates
- lipoic acid
- biotin
- iodide
- D-pantothenic acid
- D-lipoic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
- basal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc5a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sodium ion transport
- biotin metabolic process
- biotin transport
- pantothenate transmembrane transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- brush border membrane
- membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- biotin transporter activity
- pantothenate:sodium symporter activity
- protein binding
- pantothenate transmembrane transporter activity
- iodide transmembrane transporter activity
- sodium-dependent multivitamin transmembrane transporter activity