Lmbr1 Gene Summary [Rat]
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within embryonic digit morphogenesis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Laurin-Sandrow syndrome; acheiropody; and syndactyly type 4. Orthologous to human LMBR1 (limb development membrane protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmbr1 |
| Official Name | limb development membrane protein 1 [Source:RGD Symbol;Acc:1563910] |
| Ensembl ID | ENSRNOG00000059589 |
| Bio databases IDs | |
| Aliases | limb development membrane protein 1 |
| Synonyms | 1110048D14RIK, ACHP, C79130, C7ORF2, DIF14, limb development membrane protein 1, limb region 1, LSS, PPD2, RGD1563910, THYP, TPT, TPTPS, ZRS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lmbr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LMBR1-like membrane protein
- protein binding
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lmbr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- embryonic digit morphogenesis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding