Sts Gene Summary [Rat]
Enables steryl-sulfatase activity. Involved in several processes, including response to estrogen; response to pH; and response to peptide hormone. Located in endoplasmic reticulum membrane and nuclear envelope. Biomarker of cryptorchidism and hypertension. Human ortholog(s) of this gene implicated in X-linked ichthyosis. Orthologous to human STS (steroid sulfatase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sts |
| Official Name | steroid sulfatase [Source:RGD Symbol;Acc:3783] |
| Ensembl ID | ENSRNOG00000032487 |
| Bio databases IDs | |
| Aliases | steroid sulfatase |
| Synonyms | ARSC, ARSC1, ARYLSULFATASE C, ASC, ES, SSDD, Steroid Sulfatase, STEROID SULPHATASE, SULFATASE, sulphATASE, XLI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sts often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Domain of unknown function (DUF4976)
- steryl-sulfatase
- sulfuric ester hydrolase
- Sulfatase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked ichthyosis
- endometriosis
- impaired glucose tolerance
- estrogen receptor positive breast cancer
role in cell
- expression in
- synthesis in
- response
- proliferation
- enzalutamide resistance
- downregulation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- endosomes
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- nuclear envelope
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sts gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- steroid catabolic process
- epidermis development
- female pregnancy
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- endosome
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- sulfuric ester hydrolase activity
- metal ion binding
- arylsulfatase activity
- steryl-sulfatase activity