Tmc4 Gene Summary [Rat]
Predicted to enable mechanosensitive monoatomic ion channel activity and voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Predicted to be located in plasma membrane. Orthologous to human TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmc4 |
| Official Name | transmembrane channel-like 4 [Source:RGD Symbol;Acc:1304811] |
| Ensembl ID | ENSRNOG00000059741 |
| Bio databases IDs | |
| Aliases | transmembrane channel-like 4 |
| Synonyms | LOC100909619, Tmc4b, transmembrane channel-like 4, transmembrane channel-like gene family 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel
- protein binding
- voltage-gated chloride channel
- ion channel
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- mechanically-gated ion channel activity