Krt78 Gene Summary [Rat]
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in cornified envelope and keratin filament. Orthologous to human KRT78 (keratin 78). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt78 |
| Official Name | keratin 78 [Source:RGD Symbol;Acc:1591341] |
| Ensembl ID | ENSRNOG00000059790 |
| Bio databases IDs | |
| Aliases | keratin 78 |
| Synonyms | CK-78, K5B, K78, Kb40, keratin 78 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt78 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microtubule-binding protein MIP-T3 C-terminal region
- Nuf2, DHR10-like domain
- Rabaptin-like protein
- type III secretion apparatus protein, HrpE/YscL family
- TPR/MLP1/MLP2-like protein
- protein binding
- Secreted virulence factor YukE/EsxA, WXG100 family [Defense mechanisms]
- FlgN protein
- Type III secretion protein YscO
- Effector-associated domain 9
- Mechanosensitive ion channel porin domain
- Proteins of 100 residues with WXG
- Intermediate filament protein
- Centrosomal protein of 63 kDa
Pathways
Biological processes and signaling networks where the Krt78 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt78 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinization
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- keratin filament
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding