Wtap Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in mRNA processing and regulation of alternative mRNA splicing, via spliceosome. Predicted to be located in cytoplasm; nuclear membrane; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human WTAP (WT1 associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wtap |
| Official Name | WT1 associated protein [Source:RGD Symbol;Acc:1563824] |
| Ensembl ID | ENSRNOG00000019091 |
| Bio databases IDs | |
| Aliases | WT1 associated protein |
| Synonyms | 2810408K05Rik, 9430038B09RIK, KIAA0105, Mum2, RGD1563824, WT1 associated protein, WT1 associating protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wtap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WTAP/Mum2p family
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diffuse large B-cell lymphoma
- nonalcoholic steatohepatitis
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- soft tissue sarcoma cancer
- organismal death
- liver cancer
- epithelial cancer
- rhabdomyosarcoma
role in cell
- expression in
- growth
- cellular infiltration by
- apoptosis
- phosphorylation in
- number
- differentiation
- migration
- proliferation
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wtap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- mRNA processing
- mRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding