Mecp2 Gene Summary [Rat]
Enables several functions, including DNA binding activity; histone deacetylase binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including central nervous system development; positive regulation of dense core granule transport; and regulation of dendrite extension. Located in chromatin. Part of protein-containing complex. Is active in glutamatergic synapse. Used to study Rett syndrome. Biomarker of fetal alcohol spectrum disorder; hepatocellular carcinoma; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mecp2 |
| Official Name | methyl CpG binding protein 2 [Source:RGD Symbol;Acc:3075] |
| Ensembl ID | ENSRNOG00000056659 |
| Bio databases IDs | |
| Aliases | methyl CpG binding protein 2 |
| Synonyms | 1500041B07Rik, AUTSX3, D630021H01RIK, Mbd5, Mecp2 Beta, Mecp2 β, methyl-CpG binding protein 2, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mecp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- mRNA binding
- transcription co-repressor
- DNA secondary structure binding
- protein binding activity, bridging
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein domain specific binding
- protein binding
- identical protein binding
- DNA binding
- RNA binding
- unmethylated CpG binding
- transcription repression domain
- double-stranded DNA binding
- NCoR/SMRT interaction domain
- methyl-CpG binding
- corepressor binding domain
- AT hook domain
- MBD
Pathways
Biological processes and signaling networks where the Mecp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- schizophrenia
- epilepsy
- seizures
- pain
- ataxia
- weight gain
- COVID-19
- obesity
- Rett syndrome
role in cell
- apoptosis
- cell death
- expression in
- proliferation
- activation in
- fragmentation
- binding in
- migration
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- heterochromatin
- Cytoplasm
- centrosome
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- spindle pole
- chromatin
- pericentric heterochromatin
- heterochromatic compartments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mecp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- post-embryonic development
- protein localization
- negative regulation of astrocyte differentiation
- visual learning
- adult locomotory behavior
- striatum development
- regulation of respiratory gaseous exchange by neurological system process
- thalamus development
- spinal cord development
- lung alveolus development
- response to hypoxia
- catecholamine secretion
- negative regulation of transcription, DNA-dependent
- negative regulation of primary miRNA processing
- positive regulation of synaptic plasticity
- cardiolipin metabolic process
- long-term synaptic potentiation
- response to ionizing radiation
- regulation of excitatory postsynaptic membrane potential
- regulation of synapse organization
- cerebellum development
- negative regulation of dendritic spine development
- response to cocaine
- positive regulation of dendritic spine development
- positive regulation of microtubule nucleation
- respiratory gaseous exchange
- cerebral cortex development
- principal sensory nucleus of trigeminal nerve development
- cellular biogenic amine metabolic process
- long-term memory
- ventricular system development
- negative regulation of gene expression
- synapse assembly
- phosphatidylcholine metabolic process
- Notch signaling pathway
- proprioception
- heterochromatin assembly
- response to estradiol stimulus
- sensory perception of pain
- gene expression
- cellular response to potassium ion
- oligodendrocyte development
- inositol metabolic process
- response to other organism
- glutamine metabolic process
- neuron maturation
- negative regulation of smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- startle response
- ventricular cardiac muscle tissue development
- genetic imprinting
- cellular response to isoquinoline alkaloid
- dendrite development
- social behavior
- negative regulation of blood vessel endothelial cell migration
- negative regulation of locomotion involved in locomotory behavior
- positive regulation of glial cell proliferation
- hippocampus development
- hypermethylation of CpG island
- glucocorticoid metabolic process
- behavioral fear response
- neurological system process involved in regulation of systemic arterial blood pressure
- glial cell proliferation
- response to lead ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- heterochromatin
- centrosome
- extracellular space
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- protein domain specific binding
- double-stranded methylated DNA binding
- identical protein binding
- histone deacetylase binding
- siRNA binding
- unmethylated CpG binding
- chromatin binding
- methyl-CpG binding
- four-way junction DNA binding
- nucleic acid binding
- DNA binding
- RNA binding
- protein binding
- transcription corepressor activity
- mRNA binding
- binding, bridging