H1f5 Gene Summary [Rat]
Predicted to enable double-stranded DNA binding activity; histone deacetylase binding activity; and nucleosomal DNA binding activity. Predicted to be involved in several processes, including establishment of protein localization to chromatin; negative regulation of nucleobase-containing compound metabolic process; and protein stabilization. Predicted to act upstream of or within muscle organ development. Predicted to be located in heterochromatin; nucleolus; and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in euchromatin and nucleus. Orthologous to human H1-5 (H1.5 linker histone, cluster member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | H1f5 |
| Official Name | H1.5 linker histone, cluster member [Source:RGD Symbol;Acc:1590638] |
| Ensembl ID | ENSRNOG00000060355 |
| Bio databases IDs | |
| Aliases | H1.5 linker histone, cluster member |
| Synonyms | H1.5 linker histone, cluster member, H1B, H1F5, H1s-3, HIST1H1B, LOC682425 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat H1f5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- linker histone H1 and H5 family
- H15
- histone deacetylase binding
- chromatin binding
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the H1f5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- latent tuberculosis
- nonsyndromic cleft lip and palate
- inguinal hernia
regulates
- SIRT1
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- AXIN2
role in cell
- expression in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- heterochromatin
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat H1f5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- negative regulation of transcription from RNA polymerase II promoter
- chromosome condensation
- establishment of protein localization to chromatin
- chromatin organization
- protein stabilization
- nucleosome assembly
- negative regulation of DNA recombination
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- euchromatin
- chromosome
- nucleolus
- nucleosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- structural constituent of chromatin
- RNA binding
- protein binding
- histone deacetylase binding
- nucleosomal DNA binding
- double-stranded DNA binding