GeneGlobe ID: PAHS-018Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays

RT² Profiler™ PCR Array Human Toll-Like Receptor Signaling Pathway

RT2 Profiler PCR Array
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Product Specification

Target List
Toll-Like Receptors
CD180, SIGIRR, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10
Pathogen-Specific Responses
Bacterial Response​
CCL2 (MCP-1), CD14, CD180, FOS, HRAS, IL10, IL12A, IL1B, IL6, CXCL8 (IL8), IRAK1, HMGB1, HSPA1A (HSP70-1A), JUN, LTA (TNFB), LY86 (MD-1), LY96 (MD-2), NFKBIA (IκBα, MAD3), PTGS2 (COX2), RELA, RIPK2, TLR2, TLR4, TLR6, TNFRSF1A (TNFR1), TICAM1 (TRIF)
Viral Response​
EIF2AK2, IFNB1, IFNG, IL12A, IL6, IRF3, PRKRA, RELA, TBK1, TLR3, TLR7, TLR8, TNF, TICAM1 (TRIF)
Fungal / Parasitic Response​
CLEC4E, HRAS, HSPA1A (HSP70-1A), CXCL8 (IL8), TLR2, TIRAP
Toll-Like Receptor (TLR) Signaling
Negative Regulation of Toll-Like Receptor (TLR) Signaling​
SARM1, SIGIRR, TOLLIP
TICAM1 (TRIF)-Dependent (MYD88-Independent) Signaling​
IRF3, MAP3K7 (TAK1), TAB1, NR2C2 (TAK1), PELI1, TBK1, TICAM2 (TRAM), TLR3, TLR4, TRAF6, TICAM1 (TRIF)
MYD88-Dependent Signaling​
IRAK1, IRAK2, MAP3K7 (TAK1), TAB1, MYD88, NR2C2 (TAK1), TIRAP, TLR1, TLR10, TLR2, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TRAF6
Signaling Downstream of Toll-Like Receptors
NFκB Signaling​
BTK, CASP8 (FLICE), CHUK (IKKα), ECSIT, FADD, IKBKB (IKKβ), IL10, IL1B, IRAK1, IRAK2, IRF3, LY96 (MD-2), MAP3K1 (MEKK1), MAP3K7 (TAK1), MAP4K4, NFKB1, NFKB2, NFKBIA (IκBα, MAD3), NFKBIL1, NFRKB, PPARA, REL, RELA, TNF, TNFRSF1A (TNFR1), UBE2N
JNK / p38 Signaling​
ELK1, FOS, IL1B, JUN, MAP2K3 (MEK3), MAP2K4 (MKK4, JNKK1), MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK8 (JNK1), MAPK8IP3, TNF
JAK / STAT Signaling​
CCL2 (MCP-1), CSF2 (GM-CSF), IFNG, IL12A, IL2, IL6
Interferon Regulatory Factor (IRF) Signaling​
CXCL10 (INP10), IFNA1, IFNB1, IFNG, IRF1, IRF3, TBK1
Cytokine Signaling​
CCL2 (MCP-1), CSF3 (GCSF), IL1A, IL1B, IL6, IRAK1, IRAK2, RELA, SIGIRR, TNF, TNFRSF1A (TNFR1)
Regulation of Adaptive Immunity
CD80, CD86, HSPD1, IFNG, IL10, IL12A, IL1B, IL2, MAP3K7 (TAK1), TRAF6
Toll-Like Receptor Interacting Proteins & Adaptors
BTK, CD14, HMGB1, HRAS, HSPA1A (HSP70-1A), HSPD1, LY86 (MD-1), LY96 (MD-2), MAPK8IP3, MYD88, PELI1, RIPK2, SARM1, TICAM1 (TRIF), TICAM2 (TRAM), TIRAP, TOLLIP
Downstream Effectors of Toll-Like Receptor Signaling
CASP8 (FLICE), EIF2AK2, FADD, IRAK1, IRAK2, IRAK4, MAP3K7 (TAK1), TAB1, NR2C2 (TAK1), PPARA, PRKRA, ECSIT, TRAF6, UBE2N
Gene Resource List
Array Layout for PCR Plates
File Size: 139.1 KBLanguage: English
Array Layout for Rotor-Gene Q
File Size: 133.59 KBLanguage: English

Resources

Brochures & Guides (3)
Simultaneously profile mRNA, miRNA and lncRNA using a simple, complete workflow
Download Files (3)
For analyzing gene expression data from RT2 Profiler PCR Arrays 
Data analysis file for RT² Profiler PCR Array Housekeeping Genes
Catalog number- 330231
Pathway number- PAXX-000
RNA QC Data Analysis
XLS (484KB)

Data analysis file for RT² ProfilerRT² Profiler™ PCR Array RT2 RNA QC
Catalog number- 330231
Pathway number- PAXX-999

Scientific Posters (1)
Poster for download
Kit Handbooks (1)
For pathway-focused gene expression profiling using real-time RT-PCR
Instrument Technical Documents (2)
For gene expression and genomic analysis
For pathway-focused gene expression analysis
Certificates of Analysis (1)
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