Target List
Toll-Like Receptor (TLR) Signaling
Toll-Like Receptors & Chaperones​
CTSB, CTSL, CTSS, TLR3, TLR7, TLR8, TLR9
Signaling Downstream of Toll-Like Receptors​
CHUK (IKKα), FOS, IKBKB (IKKβ), IRAK1, IRF3, IRF5, IRF7, JUN, MAP2K1, MAP2K3 (MEK3), MAP3K7 (TAK1), MAPK1 (ERK2), MAPK14 (p38ALPHA), MAPK3 (ERK1), MAPK8 (JNK1), MYD88, NFKB1, NFKBIA (IκBα, MAD3), RELA, RIPK1, SPP1, TBK1, TICAM1 (TRIF), TNF, TRAF3, TRAF6
Toll-Like Receptor Signaling Responsive Genes​
CCL3 (MIP-1A), CCL5 (RANTES), CD40 (TNFRSF5), CD80, CD86, CXCL10 (INP10), CXCL11 (I-TAC, IP-9), CXCL9 (MIG), IFNA1, IFNA2, IFNB1, IL12A, IL12B, IL15, IL1B, IL6
NOD-Like Receptor (NLR) Signaling
Receptors & Signaling Molecules​
AIM2
NOD-Like Receptors & Signaling Molecules​
CARD9, CASP1 (ICE), HSP90AA1, MEFV, NLRP3, NOD2, OAS2, PSTPIP1, PYCARD (TMS1, ASC), PYDC1 (POP1), SUGT1
NOD-Like Receptor Signaling Responsive Genes​
IL1B, IL18
RIG-I-Like Receptor Signaling
Receptors & Chaperones​
CYLD
RIG-I-Like Receptors & Chaperones​
TKFC, DDX58, DHX58, IFIH1, ISG15, TRIM25
Signaling Downstream of RIG-I-Like Receptors​
ATG5, AZI2, CASP10 (MCH4), CASP8 (FLICE), CHUK (IKKα), DDX3X, FADD, IKBKB (IKKβ), IRF3, IRF7, MAP3K1 (MEKK1), MAP3K7 (TAK1), MAPK14 (p38ALPHA), MAPK8 (JNK1), MAVS, NFKB1, NFKBIA (IκBα, MAD3), PIN1, RELA, RIPK1, TBK1, TNF, TRADD, TRAF3, TRAF6
RIG-I-Like Receptor Signaling Responsive Genes​
CXCL10 (INP10), IFNA1, IFNA2, IFNB1, IL12A, IL12B, CXCL8 (IL8)
Type I Interferon Signaling & Response
Type I Interferon Signaling​
IFNA1, IFNA2, IFNAR1, IFNB1, STAT1
Interferon Responsive Genes​
APOBEC3G, IL15, ISG15, MX1, TLR3