Target List
Inflammasomes
AIM2​
Aim2, Casp1 (Ice), Pycard (Tms1, Asc)
IPAF​
Casp1 (Ice), Naip1 (Birc1), Naip5, Nlrc4 (Ipaf), Pycard (Tms1, Asc)
NLRP1​
Casp1 (Ice), Nlrp1a
NLRP3​
Casp1 (Ice), Nlrp3, Pycard (Tms1, Asc)
Negative Regulation of Inflammasomes​
Bcl2, Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Bcl2l1 (Bcl-XL), Cd40lg, Ctsb, Hsp90aa1, Hsp90b1, Mefv, Pstpip1, Sugt1, Tnf, Tnfsf11 (Rankl), Tnfsf14, Tnfsf4 (Ox40l)
Signaling Downstream of Inflammasomes​
Ifng, Il12a, Il12b, Il18, Il1b, Il33, Irak1, Irf1, Myd88, P2rx7, Panx1, Ptgs2 (Cox2), Mok, Ripk2, Txnip
NOD-Like Receptors
NOD-Like Receptors​
Ciita, Naip1 (Birc1), Naip5, Nlrc4 (Ipaf), Nlrc5, Nlrp1a, Nlrp12 (Nalp12, PYPAF7), Nlrp3, Nlrp4b, Nlrp4e, Nlrp5, Nlrp6, Nlrp9b, Nlrx1, Nod1, Nod2
Signaling Downstream of NOD-Like Receptors​
Birc2 (cIAP1, cIAP2), Birc3 (cIAP1, cIAP2), Card6, Casp8 (Flice), Ccl12 (MCP-5, Scya12), Ccl5 (Rantes), Ccl7 (mcp3), Cflar (Casper), Chuk (IKBKA), Cxcl3, Cxcl1 (Gro1), Fadd, Ifnb1, Ikbkb (IKKbeta), Ikbkg, Il6, Irf1, Irf3, Irf4, Map3k7 (Tak1), Mapk1 (Erk2), Mapk11 (p38beta), Mapk12 (P38Gamma), Mapk13 (SAPK4, Serk4), Mapk3 (Erk1), Mapk8 (Jnk1), Mapk9 (Jnk2), Nfkb1, Nfkbia (Iκbα, Mad3), Nfkbib (Trip9), Pea15a, Rela, Ripk2, Sugt1, Tab1, Tab2, Tirap, Tnf, Traf6, Xiap
Pro-Inflammatory Caspases
Casp1 (Ice), Casp12