Abcb4 Gene Summary [Mouse]
Predicted to enable ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in bile acid secretion and response to fenofibrate. Located in intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcb4 |
| Official Name | ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569] |
| Ensembl ID | ENSMUSG00000042476 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
| Synonyms | ATP-binding cassette, sub-family B member 4, Mdr2, P Glycoprotein 2, Pgy-2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- type I secretion system ABC transporter, PrtD family
- Conjugate Transporter-2 (CT2) Family protein
- nitrate transport ATP-binding subunits C and D
- urea ABC transporter, ATP-binding protein UrtE
- heme ABC exporter, ATP-binding protein CcmA
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- phosphatidylcholine transporter
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNP-ATP
- NR1I3
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- hypocalcemia
- bleeding
- fibrosis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
phenotypes
- abnormal behavior
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- hypoactivity
- increased leukocyte cell number
- increased monocyte cell number
- increased red blood cell distribution width
- increased spleen weight
- increased startle reflex
- thrombocytosis
- abnormal bile canaliculus morphology
- abnormal bile composition
- abnormal bile duct morphology
- abnormal bile secretion
- abnormal blood homeostasis
- abnormal bone remodeling
- abnormal circulating alanine transaminase level
- abnormal circulating alkaline phosphatase level
- abnormal circulating aspartate transaminase level
- abnormal circulating bilirubin level
- abnormal circulating enzyme level
- abnormal compact bone morphology
- abnormal enzyme/coenzyme activity
- abnormal feces composition
- abnormal gallbladder size
- abnormal hepatobiliary system morphology
- abnormal hepatobiliary system physiology
- abnormal hepatocyte morphology
- abnormal intestine physiology
- abnormal lipid homeostasis
- abnormal liver morphology
- abnormal portal triad morphology
- abnormal sodium ion homeostasis
- abnormal trabecular bone morphology
- abnormal trabecular bone volume
- bile duct inflammation
- bile duct proliferation
- biliary cirrhosis
- cholestasis
- decreased bone mineral content
- decreased bone mineral density
- decreased bone trabecula number
- decreased bone volume
- decreased circulating calcium level
- decreased circulating cholesterol level
- decreased intestinal cholesterol absorption
- decreased systemic arterial systolic blood pressure
- decreased trabecular bone connectivity density
- decreased vitamin D level
- dilated bile duct
- enlarged liver
- enlarged spleen
- focal hepatic necrosis
- gallstones
- hepatic necrosis
- increased alkaline phosphatase activity
- increased bile salt level
- increased circulating alanine transaminase level
- increased circulating alkaline phosphatase level
- increased circulating aspartate transaminase level
- increased circulating bilirubin level
- increased circulating phosphate level
- increased hepatocellular carcinoma incidence
- increased transforming growth factor level
- intrahepatic cholestasis
- liver cirrhosis
- liver fibrosis
- liver hemorrhage
- liver inflammation
- portal hypertension
- reduced female fertility
- weight loss
role in cell
- expression in
- growth
- proliferation
- cellular infiltration by
- sensitivity
- survival
- recruitment
- senescence
- abnormal morphology
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Cytoplasm
- cellular membrane
- focal adhesions
- intercellular junctions
- cytosol
- apical cell surfaces
- apical membrane
- Golgi membrane
- nucleoplasm