Mapk9 Gene Summary [Mouse]
Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including inflammatory response to wounding; positive regulation of macromolecule metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is active in Schaffer collateral - CA1 synapse and cytoplasm. Is expressed in several structures, including alimentary system; brain; future brain; genitourinary system; and olfactory epithelium. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk9 |
| Official Name | mitogen-activated protein kinase 9 [Source:MGI Symbol;Acc:MGI:1346862] |
| Ensembl ID | ENSMUSG00000020366 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 9 |
| Synonyms | JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK-55, Jnk p54, Jnk p55, mitogen-activated protein kinase 9, p54a, p54aSAPK, PRKM9, SAPK, SAPK1a, Sapk α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein interaction domain
- protein serine/threonine kinase
- protein kinase
- protein threonine/tyrosine kinase
- protein kinase binding
- ATP binding
- caspase activator
- protein binding
- alpha domain
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- JUN kinase
- alcohol group acceptor phosphotransferase
Pathways
Biological processes and signaling networks where the Mapk9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Apelin Liver Signaling Pathway
- Apelin Pancreas Signaling Pathway
- April Mediated Signaling
- B Cell Activating Factor Signaling
- CD27 Signaling in Lymphocytes
- CD40 Signaling
- CDK5 Signaling
- CXCR4 Signaling
- GADD45 Signaling
- GDNF Family Ligand-Receptor Interactions
- Glucocorticoid Receptor Signaling
- HGF Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- LPS-stimulated MAPK Signaling
- PAK Signaling
- PCP pathway
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of IL-17A in Arthritis
- Role of MAPK Signaling in the Pathogenesis of Influenza
- STAT3 Pathway
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- benign neoplasia
- non-small cell lung carcinoma
- cancer
- epithelial cancer
- metastatic colon cancer
- metastatic rectal cancer
- advanced colon cancer
- cutaneous melanoma
role in cell
- proliferation
- phosphorylation in
- apoptosis
- expression in
- transformation
- number
- binding in
- accumulation in
- colony formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nuclear speckles
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular senescence
- Fc-epsilon receptor signaling pathway
- apoptotic signaling pathway
- JNK cascade
- regulation of circadian rhythm
- protein phosphorylation
- positive regulation of cytokine production involved in inflammatory response
- rhythmic process
- positive regulation of gene expression
- cellular response to cadmium ion
- positive regulation of protein ubiquitination
- regulation of synaptic transmission
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- cellular response to reactive oxygen species
- positive regulation of podosome assembly
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine/tyrosine kinase activity
- JUN kinase activity
- protein serine/threonine kinase activity