Klhl18 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in nervous system and retina nuclear layer. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl18 |
| Official Name | kelch-like 18 [Source:MGI Symbol;Acc:MGI:2143315] |
| Ensembl ID | ENSMUSG00000054792 |
| Bio databases IDs | |
| Aliases | kelch-like 18 |
| Synonyms | A930041K15, kelch-like 18, kelch-like family member 18, RGD1310570 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- protein ubiquitination
Molecular Function
What the gene product does at the molecular level
- protein binding