Shisa6 Gene Summary [Mouse]
Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and testis. Orthologous to human SHISA6 (shisa family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Shisa6 |
| Official Name | shisa family member 6 [Source:MGI Symbol;Acc:MGI:2685725] |
| Ensembl ID | ENSMUSG00000053930 |
| Bio databases IDs | |
| Aliases | shisa family member 6 |
| Synonyms | ckamp52, Gm879, LOC284033, RGD1564618, shisa family member 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shisa6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt and FGF inhibitory regulator
- protein binding
- ionotropic glutamate receptor binding
- PDZ-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic membrane
- synapse
- postsynaptic density
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shisa6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- spermatogenesis
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
- Wnt receptor signaling pathway
- regulation of short-term neuronal synaptic plasticity
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- postsynaptic density
- postsynaptic membrane
- dendritic spine membrane
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- protein binding
- PDZ domain binding