Cops3 Gene Summary [Mouse]
Acts upstream of or within in utero embryonic development. Part of COP9 signalosome. Is expressed in several structures, including central nervous system; inner cell mass; reproductive system; skeletal muscle tissue; and urinary system. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cops3 |
| Official Name | COP9 signalosome subunit 3 [Source:MGI Symbol;Acc:MGI:1349409] |
| Ensembl ID | ENSMUSG00000019373 |
| Bio databases IDs | |
| Aliases | COP9 signalosome subunit 3 |
| Synonyms | COP9 signalosome subunit 3, CSN3, SGN3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- protein binding
Pathways
Biological processes and signaling networks where the Cops3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- signal transduction
- protein deneddylation
- protein neddylation
- response to light stimulus
- regulation of protein neddylation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding