Sugt1 Gene Summary [Mouse]
Enables lncRNA binding activity. Acts upstream of or within kinetochore assembly; skeletal muscle satellite cell proliferation; and spindle organization. Located in cytoplasm and kinetochore. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sugt1 |
| Official Name | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1915205] |
| Ensembl ID | ENSMUSG00000022024 |
| Bio databases IDs | |
| Aliases | SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) |
| Synonyms | 2410174K12RIK, Aa1114, SGT1, SGT1 homolog, MIS12 kinetochore complex assembly cochaperone, SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sugt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- SGS domain
- alpha-crystallin Hsps/p23-like
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
- RNA binding
Pathways
Biological processes and signaling networks where the Sugt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- Alzheimer disease
role in cell
- colony formation
- cell viability
- organization
- proliferation by
- destabilization in
- assembly
- misalignment in
- misalignment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear bodies
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sugt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- regulation of protein stability
- kinetochore assembly
- satellite cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytosol
- macromolecular complex
- kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding