Cfh Gene Summary [Mouse]
Enables complement component C3b binding activity and heparin binding activity. Acts upstream of or within with a positive effect on retina development in camera-type eye. Acts upstream of or within several processes, including complement activation; retina development in camera-type eye; and skeletal system development. Located in several cellular components, including axon; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including adrenal gland; bone; central nervous system; hemolymphoid system; and metanephros. Used to study age related macular degeneration 4; atypical hemolytic-uremic syndrome; hemolytic-uremic syndrome; and membranoproliferative glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to human CFH (complement factor H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfh |
| Official Name | complement component factor h [Source:MGI Symbol;Acc:MGI:88385] |
| Ensembl ID | ENSMUSG00000026365 |
| Bio databases IDs | |
| Aliases | complement component factor h |
| Synonyms | AHUS1, AMBP-1, ARMD4, ARMS1, CFH isoform 1, CFHL3, complement component factor h, complement factor H, FACTOR H, FH, HF, HF1, HF2, HUS, Mud-1, NOM, Sas-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cfh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- binding protein
- surface binding domain
- inhibitory domain
- protein binding
- Sushi repeat (SCR repeat)
- complement regulatory protein domain
- consensus repeat domain
- heparin binding
- identical protein binding
- SUSHI repeat
Pathways
Biological processes and signaling networks where the Cfh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- peripheral arterial disease
- hyperplasia
- exudative age-related macular degeneration
- visual disturbance
- factor h deficiency
- factor H-associated hemolytic uremic syndrome
- androgenic alopecia
- idiopathic pulmonary fibrosis
- age-related macular degeneration type 4
role in cell
- expression in
- production in
- survival
- apoptosis
- differentiation
- morphology
- phosphorylation in
- proliferation
- migration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- plasma membrane extracellular face
- Weibel-Palade bodies
- perikaryon
- axons
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cfh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- complement activation, alternative pathway
- regulation of complement activation
- proteolysis
- regulation of complement activation, alternative pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- complement component C3b binding
- identical protein binding
- protein binding
- heparan sulfate proteoglycan binding
- heparin binding