Smap1 Gene Summary [Mouse]
Enables GTPase activator activity and clathrin binding activity. Acts upstream of or within positive regulation of erythrocyte differentiation and regulation of clathrin-dependent endocytosis. Located in cytoplasm. Is expressed in embryo. Orthologous to human SMAP1 (small ArfGAP 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Smap1 |
| Official Name | small ArfGAP 1 [Source:MGI Symbol;Acc:MGI:2138261] |
| Ensembl ID | ENSMUSG00000026155 |
| Bio databases IDs | |
| Aliases | small ArfGAP 1 |
| Synonyms | 1700056O10Rik, 4921514B13Rik, 4921525H11Rik, small ArfGAP 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative GTP-ase activating proteins for the small GTPase, ARF
- clathrin binding
- GTPase activator
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- Putative GTPase activating protein for Arf
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of clathrin-mediated endocytosis
- positive regulation of erythrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- clathrin binding