Tsix Gene Summary [Mouse]
Acts upstream of or within inactivation of paternal X chromosome by genomic imprinting; negative regulation of transcription by RNA polymerase II; and transcription initiation-coupled chromatin remodeling. Is expressed in several structures, including early conceptus; liver; and retina nuclear layer. Orthologous to human TSIX (TSIX transcript, XIST antisense RNA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | Tsix |
| Official Name | X (inactive)-specific transcript, opposite strand [Source:MGI Symbol;Acc:MGI:1336196] |
| Ensembl ID | ENSMUSG00000085715 |
| Bio databases IDs | |
| Aliases | X (inactive)-specific transcript, opposite strand |
| Synonyms | LINC00013, NCRNA00013, TSIX transcript, XIST antisense RNA, X (inactive)-specific transcript, opposite strand, X (inactive)-specific transcript, opposite strand (Tsix), antisense, XIST-AS, XIST-AS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsix often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PRC2
disease
- gastric cancer
- acute spinal cord injury
- gastric adenocarcinoma
- gastric epithelial cancer
- diffuse cutaneous systemic sclerosis
- chronic spinal cord injury
phenotypes
- abnormal DNA methylation
- abnormal allantois morphology
- abnormal chorion morphology
- abnormal developmental patterning
- abnormal digestive system physiology
- abnormal dosage compensation by inactivation of X chromosome
- abnormal ectoplacental cavity morphology
- abnormal ectoplacental cone morphology
- abnormal embryo development
- abnormal extraembryonic coelom morphology
- abnormal gastrulation
- abnormal germ layer development
- abnormal imprinting
- abnormal mesoderm development
- abnormal visceral yolk sac morphology
- absent egg cylinders
- decreased litter size
- decreased survivor rate
- embryonic lethality at implantation incomplete penetrance
- prenatal lethality
- prenatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- preweaning lethality incomplete penetrance
- small amniotic cavity
role in cell
- expression in
- activation
- inactivation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus