Ctcf Gene Summary [Mouse]
Enables chromatin binding activity and cis-regulatory region sequence-specific DNA binding activity. Involved in chromatin looping; negative regulation of gene expression; and positive regulation of gene expression. Acts upstream of or within several processes, including cardiac muscle cell development; epigenetic regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 21; basal cell carcinoma; female breast cancer; skin melanoma; and skin squamous cell carcinoma. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ctcf |
| Official Name | CCCTC-binding factor [Source:MGI Symbol;Acc:MGI:109447] |
| Ensembl ID | ENSMUSG00000005698 |
| Bio databases IDs | |
| Aliases | CCCTC-binding factor |
| Synonyms | CCCTC-binding factor, CFAP108, FAP108, MRD21, Transcription Repressor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctcf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- C2H2-type zinc-finger domain
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- zinc ion binding
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- precursor B-cell acute lymphoblastic leukemia
- non-insulin-dependent diabetes mellitus
- cancer
- neoplasia
- COVID-19
- liver cancer
- epithelial cancer
- central nervous system cancer
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
role in cell
- expression in
- invasion by
- migration
- differentiation
- apoptosis
- proliferation
- adipogenesis
- transactivation in
- growth
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cell surface
- granular components
- dense fibrillar component
- chromosome
- nucleoplasm
- nucleoli
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctcf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- chromosome segregation
- hypermethylation of CpG island
- positive regulation of transcription from RNA polymerase II promoter
- regulation of gene expression, epigenetic
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- genetic imprinting
- protein localization to chromosome, centromeric region
- regulation of centromeric sister chromatid cohesion
Cellular Component
Where in the cell the gene product is active
- condensed chromosome
- nucleus
- nucleolus
- chromosome, centromeric region
- male germ cell nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- zinc ion binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin insulator sequence binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription