HAO2 Gene Summary [Human]
This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | HAO2 |
| Official Name | hydroxyacid oxidase 2 [Source:HGNC Symbol;Acc:HGNC:4810] |
| Ensembl ID | ENSG00000116882 |
| Bio databases IDs | |
| Aliases | hydroxyacid oxidase 2, (S)-2-hydroxy-acid oxidase, glycolate oxidase, long-chain L-2-hydroxy acid oxidase, growth-inhibiting protein 16 |
| Synonyms | GIG16, Hao3, HAOX2, Haox3, hydroxyacid oxidase 2, LCHAO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HAO2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIM-like beta/alpha barrel domains
- FMN binding
- (S)-2-hydroxy-acid oxidase
- FMN-dependent dehydrogenase
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- senile lentigo
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hepatocellular carcinoma
regulates
- fatty acid
- mandelic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HAO2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid oxidation
- fatty acid alpha-oxidation
Cellular Component
Where in the cell the gene product is active
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- (S)-2-hydroxy-acid oxidase activity
- protein binding
- FMN binding