EIF4G3 Gene Summary [Human]
The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | EIF4G3 |
| Official Name | eukaryotic translation initiation factor 4 gamma 3 [Source:HGNC Symbol;Acc:HGNC:3298] |
| Ensembl ID | ENSG00000075151 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4 gamma 3 |
| Synonyms | 1500002J22Rik, 4833436O05, 4930523M17Rik, eIF-4-gamma II, eIF4GII, eIF-4-γ II, eukaryotic translation initiation factor 4 gamma 3, eukaryotic translation initiation factor 4 gamma, 3, eukaryotic translation initiation factor 4 γ 3, eukaryotic translation initiation factor 4 γ, 3, G1-419-52, Gm32394, repro8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EIF4G3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- MA3 domain
- RNA cap binding
- MIF4G domain
- eIF4-gamma/eIF5/eIF2-epsilon
- translation initiation factor
- protein binding
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- translation regulator
Pathways
Biological processes and signaling networks where the EIF4G3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- post-operative acute kidney injury
- COVID-19
- idiopathic scoliosis
- Klinefelter syndrome
- neonatal late-onset sepsis
- neuroticism
- depressive disorder
- Turner syndrome
regulates
- luciferase
role in cell
- formation
- formation in
- density
- translation in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- organelle
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EIF4G3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- spermatid development
- negative regulation of autophagy
- translational initiation
- regulation of translational initiation
Cellular Component
Where in the cell the gene product is active
- eukaryotic translation initiation factor 4F complex
- cytosol
- intracellular non-membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- RNA cap binding
- mRNA binding
- translation factor activity, nucleic acid binding