ZNF703 Gene Summary [Human]
Predicted to enable DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to estradiol stimulus; mammary gland epithelial cell differentiation; and positive regulation of mammary gland epithelial cell proliferation. Located in cytoplasm and nuclear matrix. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF703 |
| Official Name | zinc finger protein 703 [Source:HGNC Symbol;Acc:HGNC:25883] |
| Ensembl ID | ENSG00000183779 |
| Bio databases IDs | |
| Aliases | zinc finger protein 703, zinc finger elbow-related proline domain protein 1 |
| Synonyms | 1110032O19RIK, AL022941, Csmn1, End2, FLJ14299, LOC684528, NLZ1, ZEPPO1, Zfp703, zinc finger protein 703, ZNF503L, ZPO1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF703 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ductal breast carcinoma
- ductal breast cancer
- androgenic alopecia
role in cell
- proliferation
- differentiation
- apoptosis
- migration
- formation in
- assembly
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- nuclear matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF703 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of homotypic cell-cell adhesion
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- mammary gland epithelial cell differentiation
- positive regulation of epithelial to mesenchymal transition
- cellular response to estradiol stimulus
- negative regulation of transcription, DNA-dependent
- regulation of canonical Wnt receptor signaling pathway
- regulation of cell cycle
- adherens junction assembly
- regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of mammary gland epithelial cell proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear matrix
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding