Hao2 Gene Summary [Rat]
Enables (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and identical protein binding activity. Involved in mandelate metabolic process. Located in peroxisome. Orthologous to human HAO2 (hydroxyacid oxidase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hao2 |
| Official Name | hydroxyacid oxidase 2 [Source:RGD Symbol;Acc:70972] |
| Ensembl ID | ENSRNOG00000019470 |
| Bio databases IDs | |
| Aliases | hydroxyacid oxidase 2 |
| Synonyms | GIG16, Hao3, HAOX2, Haox3, hydroxyacid oxidase 2, LCHAO |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hao2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIM-like beta/alpha barrel domains
- FMN binding
- (S)-2-hydroxy-acid oxidase
- FMN-dependent dehydrogenase
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- senile lentigo
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- hepatocellular carcinoma
regulates
- fatty acid
- mandelic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hao2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid oxidation
- fatty acid alpha-oxidation
Cellular Component
Where in the cell the gene product is active
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- (S)-2-hydroxy-acid oxidase activity
- protein binding
- FMN binding