TRIM7 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | TRIM7 |
| Official Name | tripartite motif containing 7 [Source:HGNC Symbol;Acc:HGNC:16278] |
| Ensembl ID | ENSG00000146054 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 7, glycogenin-interacting protein, tripartite motif protein TRIM7 |
| Synonyms | AL645849.2, GNIP, RNF90, tripartite motif-containing 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- Apolipoprotein A1/A4/E domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- monoclonal gammopathy of undertermined significance
- glioma formation
- carcinoma
- breast cancer
- ischemic cardiomyopathy
- asthma
- Alzheimer disease
- glioblastoma
- glioblastoma cancer
regulated by
- doxorubicin
- ETV6-RUNX1
- A549 cells
- METTL3
- THP-1 cells
regulates
- 2Bc
- POLY
- glycogenin
role in cell
- degradation in
- inhibition in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding