Thada Gene Summary [Mouse]
Predicted to enable enzyme regulator activity. Predicted to be involved in negative regulation of endoplasmic reticulum calcium ion concentration and tRNA nucleoside ribose methylation. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including cartilage; male reproductive gland or organ; nervous system; parathyroid gland; and trachea. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Thada |
| Official Name | thyroid adenoma associated [Source:MGI Symbol;Acc:MGI:3039623] |
| Ensembl ID | ENSMUSG00000024251 |
| Bio databases IDs | |
| Aliases | thyroid adenoma associated |
| Synonyms | 6530405K19, A930021O22, ARMC13, AU019899, GITA, RGD1560519, THADA armadillo repeat containing, THADA, armadillo repeat containing, thyroid adenoma associated, Trm732 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Thada often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- THADA/TRM732, DUF2428
- protein binding
- enzyme regulator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- epithelial cancer
- cancer
- myocardial infarction
- psoriasis
- prostate cancer
- non-insulin-dependent diabetes mellitus
- inflammatory bowel disease
- hypertension
- prostatic carcinoma
regulated by
- thapsigargin
- metformin
- STAT5B
- EAhy926 cells
regulates
- Ca2+
- lipid
- D-glucose
- CASP8
- insulin
role in cell
- apoptosis
- molecular cleavage in
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Thada gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA nucleoside ribose methylation
- lipid homeostasis
- reduction of endoplasmic reticulum calcium ion concentration
- tRNA methylation
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme regulator activity