Stau1 Gene Summary [Mouse]
Enables RNA binding activity. Involved in dendritic transport of messenger ribonucleoprotein complex. Acts upstream of or within intracellular mRNA localization. Located in cytoplasmic stress granule and neuron projection. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; gonad; and sensory organ. Orthologous to human STAU1 (staufen double-stranded RNA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stau1 |
| Official Name | staufen double-stranded RNA binding protein 1 [Source:MGI Symbol;Acc:MGI:1338864] |
| Ensembl ID | ENSMUSG00000039536 |
| Bio databases IDs | |
| Aliases | staufen double-stranded RNA binding protein 1 |
| Synonyms | 5830401L18Rik, PPP1R150, STAU, Staufen, staufen double-stranded RNA binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stau1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding domain
- protein phosphatase 1 binding
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- protein binding
- dsRNA-binding domain
- Staufen C-terminal domain
- transporter
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- schizophrenia
- major depression
- insomnia
- Alzheimer disease
- infection by Dengue virus 2
role in cell
- proliferation
- expression in
- production in
- apoptosis
- growth
- formation
- localization in
- transport in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- polyribosome fractions
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- microtubules
- microtubule bundles
- granules
- cytosol
- nucleoli
- neurofilaments
- neurites
- rough endoplasmatic reticulum
- actin stress fibers
- stress granule
- membrane processes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stau1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- intracellular mRNA localization
- positive regulation of long-term synaptic potentiation
- cellular response to oxidative stress
- protein localization to synapse
- positive regulation of viral genome replication
- positive regulation of viral protein levels in host cell
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- rough endoplasmic reticulum
- endoplasmic reticulum
- neuronal cell body
- neuron projection
- plasma membrane
- microtubule associated complex
- dendrite
- extracellular vesicular exosome
- cytoplasm
- membrane
- cell body
- dendrite cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- double-stranded RNA binding
- mRNA binding
- protein phosphatase 1 binding