THADA Gene Summary [Human]

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]

Details

Type
Protein Coding
Official Symbol
THADA
Official Name
THADA armadillo repeat containing [Source:HGNC Symbol;Acc:HGNC:19217]
Ensembl ID
ENSG00000115970
Bio databases IDs NCBI: 63892 Ensembl: ENSG00000115970
Aliases THADA armadillo repeat containing, Trm732 homolog (S. cerevisiae)
Synonyms 6530405K19, A930021O22, ARMC13, AU019899, GITA, RGD1560519, THADA armadillo repeat containing, THADA, armadillo repeat containing, thyroid adenoma associated, Trm732
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THADA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • THADA/TRM732, DUF2428
  • protein binding
  • enzyme regulator activity

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metabolic syndrome X
  • epithelial cancer
  • cancer
  • myocardial infarction
  • psoriasis
  • prostate cancer
  • non-insulin-dependent diabetes mellitus
  • inflammatory bowel disease
  • hypertension
  • prostatic carcinoma
regulated by
  • thapsigargin
  • metformin
  • STAT5B
  • EAhy926 cells
regulates
role in cell
  • apoptosis
  • molecular cleavage in
  • mass

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human THADA gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • tRNA nucleoside ribose methylation
  • lipid homeostasis
  • reduction of endoplasmic reticulum calcium ion concentration
  • tRNA methylation

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • enzyme regulator activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.