CDKN2B-AS1 Gene Summary [Human]
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
Details
| Type | Long Non-Coding RNA |
| Official Symbol | CDKN2B-AS1 |
| Official Name | CDKN2B antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:34341] |
| Ensembl ID | ENSG00000240498 |
| Bio databases IDs | |
| Aliases | CDKN2B antisense RNA 1, antisense RNA in the INK4 locus, non-protein coding RNA 89, p15 antisense RNA, CDKN2B antisense RNA (non-protein coding), prostate cancer associated transcript 12 |
| Synonyms | ANRIL, CDKN2B antisense RNA 1, CDKN2B-AS, Gm12610, NCRNA00089, p15AS, PCAT12 |
| Species | Human, Homo sapiens |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- endometrial carcinoma
- diabetes mellitus
- COVID-19
- prostate cancer
- squamous cell lung cancer
- chronic lymphocytic leukemia
- glaucoma
- epithelial basal cell carcinoma
role in cell
- expression in
- apoptosis
- proliferation
- cell viability
- colony survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDKN2B-AS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin assembly