CUX1 Gene Summary [Human]
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | CUX1 |
| Official Name | cut like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2557] |
| Ensembl ID | ENSG00000257923 |
| Bio databases IDs | |
| Aliases | cut like homeobox 1, golgi integral membrane protein 6, CUX1 gene Alternatively Spliced Product |
| Synonyms | CASP, CDP, CDP1, CDP2, CDP/Cut, Cdp/cux, Clox, COY1, CUT, CUTL1, cut-like homeobox 1, CUX, Cux/CDP, GDDI, GOLIM6, LOC100506550, Nbla10317 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- Nuf2, DHR10-like domain
- WTAP/Mum2p family
- transcription regulator
- B-Box C-terminal domain
- Afadin- and alpha -actinin-Binding
- protein binding activity, bridging
- cyclin recognition motif
- coiled-coil domain
- chromatin binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Tropomyosin
- CASP C terminal
- homeodomain
- HOOK protein coiled-coil region
- DNA binding domain
- nucleic acid binding
- CR1 domain
- CR2 domain
- CR3 domain
- SWI5-dependent HO expression protein 3
- protein binding
- sequence-specific DNA binding
- DNA binding
- Mechanosensitive ion channel porin domain
- CUT domain
- double-stranded DNA binding
- Growth-arrest specific micro-tubule binding
- ClyA-like
- Intermediate filament protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- prostate cancer
- epithelial cancer
- epithelial neoplasia
- cancer
- headache
- global developmental delay with or without impaired intellectual development
- organismal death
- mixed neoplasia
role in cell
- apoptosis
- expression in
- growth
- phosphorylation in
- differentiation
- invasion by
- proliferation
- activation in
- activity
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
- neurites
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- intra-Golgi vesicle-mediated transport
- positive regulation of dendrite morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- Golgi membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity