ICAM1 Gene Summary [Human]
This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ICAM1 |
| Official Name | intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] |
| Ensembl ID | ENSG00000090339 |
| Bio databases IDs | |
| Aliases | intercellular adhesion molecule 1, human rhinovirus receptor |
| Synonyms | BB2, CD54, ICAM, INTERCELLULAR ADHESION MOLECULE 1, Ly-47, M90551, MALA-2, Melanoma Progression Associated Antigen, P3.58 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ICAM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- protein binding
- Fc domain
- proline rich domain
- Ig-like V domain
- Intercellular adhesion molecule (ICAM), N-terminal domain
- binding protein
- cytoplasmic domain
- immunoreceptor tyrosine-based inhibition motif
- integrin binding
- transmembrane domain
- Immunoglobulin like
- immunoglobulin-like protein domain
- intracellular domain
- membrane-proximal domain
- cytosolic tail domain
- transmembrane receptor
- transporter
Pathways
Biological processes and signaling networks where the ICAM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Apelin Endothelial Signaling Pathway
- Atherosclerosis Signaling
- CD40 Signaling
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-10 Signaling
- IL-8 Signaling
- Leukocyte Extravasation Signaling
- Neuroinflammation Signaling Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- T Cell Receptor Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
- TREM1 Signaling
- Tumoricidal Function of Hepatic Natural Killer Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- diabetes mellitus
- bleeding
- diffuse large B-cell lymphoma
regulated by
- cyclosporin
- quercetin
- atorvastatin
- bezafibrate
- fenofibrate
- fluvastatin
- erlotinib
- acetaminophen
- APP
- fingolimod
role in cell
- quantity
- number
- formation
- survival
- cell death
- expression in
- phosphorylation in
- binding in
- injury
- necrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- docking structure
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- somatodendritic region
- membrane surface
- cellular membrane
- focal complexes
- immunological synapses
- cell-cell contacts
- apical cell surfaces
- membrane ruffles
- plasma membrane extracellular face
- uropod
- membrane rafts
- microvilli
- axons
- exosomes
- plasma
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ICAM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- adhesion to host
- T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- heterophilic cell-cell adhesion
- cell adhesion
- regulation of ruffle assembly
- membrane to membrane docking
- positive regulation of cellular extravasation
- virion attachment, binding of host cell surface receptor
- establishment of endothelial barrier
- leukocyte cell-cell adhesion
- T cell antigen processing and presentation
- cell adhesion mediated by integrin
- regulation of leukocyte mediated cytotoxicity
- cellular response to glucose stimulus
- positive regulation of ERK1 and ERK2 cascade
- T cell extravasation
- leukocyte migration
- negative regulation of endothelial cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- focal adhesion
- membrane
- membrane raft
- external side of plasma membrane
- plasma membrane
- immunological synapse
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- signaling receptor activity
- integrin binding
- viral receptor activity