NOS2 Gene Summary [Human]
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NOS2 |
| Official Name | nitric oxide synthase 2 [Source:HGNC Symbol;Acc:HGNC:7873] |
| Ensembl ID | ENSG00000007171 |
| Bio databases IDs | |
| Aliases | nitric oxide synthase 2 |
| Synonyms | CALCIUM-INDEPENDENT NOS, Hepatocyte NOS, HEP-NOS, Inducible NOS, INOS, LOC497963, MAC-NOS, nitric oxide synthase 2, nitric oxide synthase 2, inducible, NOS, NOS2A, NOS-II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NOS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FNR_like
- FAD binding domain
- Nitric oxide synthase, oxygenase domain
- heat shock protein binding
- enzyme
- identical protein binding
- NADPH-dependent FMN reductase
- NOS_oxygenase
- NADP binding
- FMN binding
- actin binding
- cadherin binding
- oxygenase domain
- flavin adenine dinucleotide binding
- protein kinase binding
- calmodulin binding
- beta-catenin binding
- calmodulin binding domain
- nitric-oxide synthase
- enzyme binding
- flavodoxin
- heme binding domain
- protein binding
- heme binding
- cAMP-dependent protein kinase regulator
- amino acid binding
- reductase domain
- binding protein
- protein homodimerization
- active site
- PDZ binding motif
- Oxidoreductase NAD-binding domain
Pathways
Biological processes and signaling networks where the NOS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Corticotropin Releasing Hormone Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endothelin-1 Signaling
- Glucocorticoid Receptor Signaling
- HIF1α Signaling
- IL-10 Signaling
- IL-12 Signaling and Production in Macrophages
- IL-17 Signaling
- ILK Signaling
- iNOS Signaling
- LXR/RXR Activation
- MIF Regulation of Innate Immunity
- MSP-RON Signaling Pathway
- Neuroinflammation Signaling Pathway
- Osteoarthritis Pathway
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Relaxin Signaling
- Role of IL-17A in Arthritis
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Sertoli Cell-Sertoli Cell Junction Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- congestive heart failure
- neoplasia
- colon adenocarcinoma
- hypertension
- glioblastoma
- metastasis
- allodynia
- primary open-angle glaucoma
- experimental autoimmune encephalomyelitis
role in cell
- ferroptosis
- production
- proliferation
- accumulation in
- expression in
- differentiation
- adhesion
- production in
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- insoluble fractions
- cortical cytoskeleton
- peroxisomal matrix
- intracellular compartment
- Extracellular Space
- cell periphery
- intracellular space
- apical compartment
- perinuclear region
- Nucleus
- cytoplasmic aggregates
- cytosol
- primary cilia
- apical membrane
- nucleoplasm
- peroxisomes
- phagosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NOS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of guanylate cyclase activity
- negative regulation of protein catabolic process
- regulation of cytokine production involved in inflammatory response
- regulation of insulin secretion
- inflammatory response
- response to hypoxia
- peptidyl-cysteine S-nitrosylation
- defense response to Gram-negative bacterium
- nitric oxide mediated signal transduction
- negative regulation of blood pressure
- cell redox homeostasis
- circadian rhythm
- regulation of cellular respiration
- response to hormone stimulus
- defense response to bacterium
- regulation of cell proliferation
- arginine catabolic process
- negative regulation of gene expression
- response to bacterium
- positive regulation of interleukin-8 production
- innate immune response in mucosa
- superoxide metabolic process
- cellular response to lipopolysaccharide
- positive regulation of leukocyte mediated cytotoxicity
- response to lipopolysaccharide
- cellular response to xenobiotic stimulus
- cellular response to interferon-gamma
- nitric oxide biosynthetic process
- prostaglandin secretion
- positive regulation of interleukin-6 production
- positive regulation of killing of cells of other organism
Cellular Component
Where in the cell the gene product is active
- peroxisome
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- peroxisomal matrix
- plasma membrane
- cortical cytoskeleton
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- arginine binding
- calmodulin binding
- NADP binding
- tetrahydrobiopterin binding
- protein homodimerization activity
- protein binding
- nitric-oxide synthase activity
- FMN binding
- metal ion binding
- flavin adenine dinucleotide binding
- heme binding