CBX7 Gene Summary [Human]
This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided by RefSeq, Oct 2016]
Details
| Type | Processed Transcript |
| Official Symbol | CBX7 |
| Official Name | chromobox 7 [Source:HGNC Symbol;Acc:HGNC:1557] |
| Ensembl ID | ENSG00000100307 |
| Bio databases IDs | |
| Aliases | chromobox 7 |
| Synonyms | 1600014J01Rik, chromobox 7, D15ERTD417E |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CBX7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Chromatin organization modifier domain
- CBX family C-terminal motif
- CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
- protein binding activity, bridging
- chromatin binding
- protein binding
- single-stranded RNA binding
- Chromo (CHRromatin organization MOdifier) domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- organismal death
- lung carcinoma process
- epithelial cancer
- lung cancer
- epithelial neoplasia
- thoracic cancer
- endometrial cancer
- liver cancer
role in cell
- proliferation
- growth
- expression in
- migration
- acetylation in
- cell cycle progression
- sphere formation
- tumorigenicity
- colony formation
- inactivation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CBX7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- PcG protein complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding