SLC9A2

SLC9A2 Gene Summary

This gene encodes a member of the sodium-hydrogen exchanger (NHE) protein family. These proteins are involved in sodium-ion transport by exchanging intracellular hydrogen ions to external sodium ions and help in the regulation of cell pH and volume. The encoded protein is localized to the apical membrane and is involved in apical absorption of sodium. [provided by RefSeq, Jun 2016]

Details

Type
Protein Coding
Official Symbol
SLC9A2
Official Name
solute carrier family 9 member A2 [Source:HGNC Symbol;Acc:HGNC:11072]
Ensembl ID
ENSG00000115616
Bio databases IDs NCBI: 6549 Ensembl: ENSG00000115616
Aliases solute carrier family 9 member A2
Synonyms
2210416H12RIK,4932415O19,4932415O19Rik,AV333884,NHE-2,solute carrier family 9 member A2,solute carrier family 9 (sodium/hydrogen exchanger), member 2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
  • Sodium/hydrogen exchanger family
  • Na+/H+ antiporter, bacterial form
  • sodium/hydrogen exchanger 3
  • proline rich domain
  • transporter
  • sodium:hydrogen antiporter

Pathways

Biological processes and signaling networks where the SLC9A2 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • DPP4
  • USP7
  • PRKN
  • SPTAN1
  • p85 PIK3R
  • CFTR
  • LPAR2
  • SRC
  • CHP1
  • ABL1/2
disease
  • COVID-19
  • endometriosis
  • allergic asthma
  • hypochlorhydria
regulated by
  • phorbol esters
  • TBX3
  • EGF
  • tetradecanoylphorbol acetate
  • FGF
  • adenosine triphosphate
  • ESR1
  • Ifnt
  • TFF2
  • okadaic acid
regulates
  • Na+
  • ion
role in cell
  • differentiation
  • abnormal morphology
  • intracellular pH
  • pH
  • sodium/hydrogen exchange

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cellular membrane
  • apical membrane
  • basal membrane
  • brush border

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the SLC9A2 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • epithelial cell differentiation
  • regulation of intracellular pH
  • ion transport
  • potassium ion transmembrane transport
  • protein localization

CELLULAR COMPONENT

Where in the cell the gene product is active
  • membrane
  • plasma membrane
  • apical plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • potassium:hydrogen antiporter activity
  • sodium:hydrogen antiporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.