CHP1 Gene Summary [Human]
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | CHP1 |
| Official Name | calcineurin like EF-hand protein 1 [Source:HGNC Symbol;Acc:HGNC:17433] |
| Ensembl ID | ENSG00000187446 |
| Bio databases IDs | |
| Aliases | calcineurin like EF-hand protein 1, calcineurin homologous protein |
| Synonyms | 1500003O03Rik, Cahp, calcineurin-like EF-hand protein 1, CHP, p22, p24, Sid470p, SLC9A1BP, SPAX9, vac, Wrch2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- transcription regulator
- nuclear export signal
- EF-hand domain pair
- potassium channel regulator
- calcium ion binding
- EFh
- protein binding
- sodium:hydrogen antiporter
- microtubule binding
- EFh_SPARC_EC
- EF-hand domain
- kinase binding
- GTPase domain
- EF hand
Pathways
Biological processes and signaling networks where the CHP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- Axonal Guidance Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Glucocorticoid Receptor Signaling
- Gαq Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- Neuroinflammation Signaling Pathway
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plaque psoriasis
- psoriasis
- graft-vs-host disease
- myelodysplastic syndrome
- plasma cell myeloma
- acute myeloid leukemia
- chronic hepatitis C
- immunodeficiency
- acute graft-vs-host disease
- transplanted organ rejection
role in cell
- expression in
- proliferation
- cell viability
- formation
- targeting
- fusion
- formation in
- incorporation in
- synthesis in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- pH resistant lipid raft fraction
- microtubule cytoskeleton
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- Golgi membrane
- early endosomes
- transport vesicles
- membrane rafts
- presynaptic terminals
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- membrane docking
- negative regulation of protein kinase activity
- potassium ion transport
- positive regulation of phospholipid biosynthetic process
- positive regulation of protein transport
- negative regulation of calcineurin-NFAT signaling cascade
- negative regulation of protein ubiquitination
- positive regulation of protein glycosylation
- negative regulation of protein autophosphorylation
- membrane organization
- membrane fusion
- negative regulation of protein import into nucleus
- small GTPase mediated signal transduction
- negative regulation of NF-kappaB transcription factor activity
- protein export from nucleus
- regulation of intracellular pH
- positive regulation of sodium:hydrogen antiporter activity
- microtubule bundle formation
- negative regulation of phosphatase activity
- negative regulation of protein phosphorylation
- cellular response to acidity
- sodium ion transmembrane transport
- cytoplasmic microtubule organization
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- microtubule cytoskeleton
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane raft
- endoplasmic reticulum
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- transport vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- sodium:hydrogen antiporter activity
- calcium ion binding
- calcium-dependent protein binding
- protein kinase inhibitor activity
- potassium channel regulator activity
- kinase binding
- microtubule binding