TFF2 Gene Summary [Human]
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TFF2 |
| Official Name | trefoil factor 2 [Source:HGNC Symbol;Acc:HGNC:11756] |
| Ensembl ID | ENSG00000160181 |
| Bio databases IDs | |
| Aliases | trefoil factor 2 |
| Synonyms | mSP, SML1, SP, spasmolytic protein 1, trefoil factor 2, trefoil factor 2 (spasmolytic protein 1) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Trefoil
- CXCR chemokine receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- carbon tetrachloride-induced liver fibrosis
- neoplasia
- cholangiocarcinoma
- cholangiocarcinoma cancer
- ulceration
- gastric adenocarcinoma
- gastric epithelial cancer
role in cell
- proliferation
- invasion
- activation
- migration
- quantity
- phosphorylation in
- cell movement
- chemotaxis
- scattering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemokine-mediated signaling pathway
- maintenance of gastrointestinal epithelium
- negative regulation of gastric acid secretion
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- CXCR4 chemokine receptor binding
- protein binding