LPAR2 Gene Summary [Human]
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LPAR2 |
| Official Name | lysophosphatidic acid receptor 2 [Source:HGNC Symbol;Acc:HGNC:3168] |
| Ensembl ID | ENSG00000064547 |
| Bio databases IDs | |
| Aliases | lysophosphatidic acid receptor 2 |
| Synonyms | EDG-4, IPA2, LPA-2, LPA2 receptor, LPA receptor 2, lysophosphatidic acid receptor 2, RGD1561336 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LPAR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- lipid binding
- CXXC zinc finger
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- PDZ binding motif
- seven-transmembrane G protein-coupled receptor superfamily
- PDZ-domain binding
Pathways
Biological processes and signaling networks where the LPAR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- idiopathic pulmonary fibrosis
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- intimal hyperplasia
- hypersensitivity reaction type I
- cardiac fibrosis
- enteropathy
- gastric cancer
role in cell
- recruitment
- apoptosis
- expression in
- growth
- migration
- proliferation
- activation in
- formation
- cell death
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- cytosol
- presynaptic membrane
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LPAR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- regulation of metabolic process
- positive regulation of MAPK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasm
- presynaptic active zone membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid receptor activity
- G-protein coupled receptor activity
- protein binding
- PDZ domain binding
- lipid binding