ADH5

ADH5 Gene Summary

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

Details

Type
Protein Coding
Official Symbol
ADH5
Official Name
alcohol dehydrogenase 5 (class III), chi polypeptide [Source:HGNC Symbol;Acc:HGNC:253]
Ensembl ID
ENSG00000197894
Bio databases IDs NCBI: 128 Ensembl: ENSG00000197894
Aliases alcohol dehydrogenase 5 (class III), chi polypeptide, S-nitrosoglutathione reductase
Synonyms
ADH-3,Adhb2,ADHX,alcohol dehydrogenase 5 (class III), chi polypeptide,AMEDS,BMFS7,CLASS III ADH,FALDH,FDH,Glutathione Dependent Formaldehyde Dehydrogenase,GSH-FDH,GSNOR,HEL-S-60p
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • alcohol dehydrogenase
  • S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
  • electron carrier
  • S-(hydroxymethyl)glutathione dehydrogenase
  • zinc ion binding
  • MDR
  • fatty acid binding
  • Zinc-binding dehydrogenase
  • Alcohol dehydrogenase GroES-like domain
  • enzyme
  • identical protein binding
  • formaldehyde dehydrogenase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
  • NOS1
  • STIP1
  • TP53
  • RPA2
  • ZRANB1
  • SP1
  • YWHAH
  • APP
  • CAPZB
  • RPA3
disease
  • epithelial cancer
  • epithelial neoplasia
  • cancer
  • ataxia
  • neoplasia
  • liver cancer
  • liver neoplasia
  • digestive system cancer
  • abdominal cancer
  • gout
regulated by
  • NAD+
  • E. coli B5 lipopolysaccharide
  • heavy metal
  • NADPH
  • Cu2+
  • CHEK2
  • Propionibacterium acnes
  • progesterone
  • VEGFA
  • Zn2+
regulates
  • Ca2+
  • tretinoin
  • S-adenosylmethionine
  • retinol
  • cytochrome-c oxidase
  • succinate dehydrogenase
  • ethanol
  • folic acid
  • PRKN
  • hydroxypyruvaldehyde
role in cell
  • number
  • differentiation
  • degradation in
  • nitrosylation in
  • expression in
  • apoptosis
  • cell death
  • cell viability
  • fragmentation in
  • fragmentation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria
  • cytosol

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ADH5 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • respiratory system process
  • response to redox state
  • retinoid metabolic process
  • formaldehyde catabolic process
  • response to nitrosative stress
  • response to lipopolysaccharide
  • fatty acid omega-oxidation
  • positive regulation of blood pressure

CELLULAR COMPONENT

Where in the cell the gene product is active
  • extracellular vesicular exosome
  • mitochondrion
  • cytosol

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • zinc ion binding
  • identical protein binding
  • fatty acid binding
  • electron carrier activity
  • S-(hydroxymethyl)glutathione dehydrogenase activity
  • formaldehyde dehydrogenase activity
  • alcohol dehydrogenase activity, zinc-dependent

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.