Adh5 Gene Summary [Mouse]
Enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; and response to lipopolysaccharide. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adh5 |
| Official Name | alcohol dehydrogenase 5 (class III), chi polypeptide [Source:MGI Symbol;Acc:MGI:87929] |
| Ensembl ID | ENSMUSG00000028138 |
| Bio databases IDs | |
| Aliases | alcohol dehydrogenase 5 (class III), chi polypeptide |
| Synonyms | ADH-3, Adhb2, ADHX, alcohol dehydrogenase 5 (class III), chi polypeptide, AMEDS, BMFS7, CLASS III ADH, FALDH, FDH, Glutathione Dependent Formaldehyde Dehydrogenase, GSH-FDH, GSNOR, HEL-S-60p |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adh5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alcohol dehydrogenase
- S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase
- electron carrier
- S-(hydroxymethyl)glutathione dehydrogenase
- zinc ion binding
- MDR
- fatty acid binding
- Zinc-binding dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- enzyme
- identical protein binding
- formaldehyde dehydrogenase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- ataxia
- neoplasia
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- gout
regulates
- Ca2+
- tretinoin
- S-adenosylmethionine
- retinol
- cytochrome-c oxidase
- succinate dehydrogenase
- ethanol
- folic acid
- PRKN
- hydroxypyruvaldehyde
role in cell
- number
- differentiation
- degradation in
- nitrosylation in
- expression in
- apoptosis
- cell death
- cell viability
- fragmentation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adh5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory system process
- response to redox state
- retinoid metabolic process
- formaldehyde catabolic process
- response to nitrosative stress
- response to lipopolysaccharide
- fatty acid omega-oxidation
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- fatty acid binding
- electron carrier activity
- S-(hydroxymethyl)glutathione dehydrogenase activity
- formaldehyde dehydrogenase activity
- alcohol dehydrogenase activity, zinc-dependent