RPA3
RPA3 Gene Summary
Enables damaged DNA binding activity and single-stranded DNA binding activity. Involved in DNA repair and DNA replication. Part of DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPA3 |
| Official Name | replication protein A3 [Source:HGNC Symbol;Acc:HGNC:10291] |
| Ensembl ID | ENSG00000106399 |
| Bio databases IDs | |
| Aliases | replication protein A3 |
| Synonyms | C330026P08Rik,p14Rpa3,REPA3,replication protein A3,RETINOBLASTOMA protein A3,RPA,RP-A p14 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- single-stranded DNA binding
- Replication factor A protein 3
- protein binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Pathways
Biological processes and signaling networks where the RPA3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PARP2
- CDK4
- PARP1
- CEP162
- BTF3
- EIF4E2
- DNAJA1
- PKP3
- SEC62
- ZCCHC8
disease
- epithelial cancer
- neoplasia
- neuroticism
- high-grade serous carcinoma
- plexiform neurofibroma
regulated by
- Lmp2a
- bortezomib
- tretinoin
- mir-146 (includes others)
- N-(3-(aminomethyl)benzyl)acetamidine
- Caco2 cells
- PPARGC1A
- imiquimod
- IL12 (complex)
- BMP2
regulates
- WRN
- CHEK1
- ATRIP
- ATR
role in cell
- proliferation
- cell death
- mitosis
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the RPA3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- DNA replication
- double-strand break repair via homologous recombination
- telomere maintenance
- nucleotide-excision repair
- mismatch repair
- regulation of cell proliferation
- regulation of mitotic cell cycle
CELLULAR COMPONENT
Where in the cell the gene product is active
- site of double-strand break
- DNA replication factor A complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- damaged DNA binding
- single-stranded DNA binding