Psmb2 Gene Summary [Mouse]
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in embryo; extraembryonic component; and nucleus pulposus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmb2 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 2 [Source:MGI Symbol;Acc:MGI:1347045] |
| Ensembl ID | ENSMUSG00000028837 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 2 |
| Synonyms | beta 2 PROTEASOME subunit, C7-I, D4Wsu33e, HC7-I, proteasome 20S subunit beta 2, proteasome 20S subunit β 2, proteasome (prosome, macropain) subunit, beta type 2, proteasome (prosome, macropain) subunit, β type 2, β 2 PROTEASOME subunit |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- IgA nephropathy
- mantle cell lymphoma
- insulin-dependent diabetes mellitus
- proteinuria
- precursor B-cell acute lymphoblastic leukemia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- plasma cell myeloma
- symptomatic multiple myeloma
role in cell
- expression in
- growth
- killing
- reverse transcription in
- dipeptide repeat protein sensitivity
- reverse transcription
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- response to organic cyclic compound
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- membrane
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding